Complete response to brentuximab vedotin in a transplant-naïve patient with relapsed CD30-positive nodular lymphocyte-predominant Hodgkin lymphoma.
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چکیده
644.8. Schulz H, Rehwald U, Morschhauser F, et al. Rituximab in relapsed lympho-cyte-predominant Hodgkin lymphoma: long-term results of a phase 2 trial by theGerman Hodgkin Lymphoma Study Group (GHSG). Blood. 2008;111:109-111.9. Advani RH, Horning SJ, Hoppe RT, et al. Frontline therapy of nodularlymphocyte predominant Hodgkin lymphoma with rituximab: the StanfordUniversity experience. Blood (ASH Annual Meeting Abstracts). 2011;118:Abstract 2686.10. Eichenauer DA, Fuchs M, Pluetschow A, et al. Phase 2 study of ritux-imab in newly diagnosed stage IA nodular lymphocyte-predominant Hodg-kin lymphoma: a report from the German Hodgkin Study Group. Blood.2011;118:4363-4365.11. Fanale MA, Lai CM, McLaughlin P, et al. Outcomes of nodular lymphocytepredominant Hodgkin’s lymphoma (NLPHL) patients treated with R-CHOP.Blood (ASH Annual Meeting Abstracts). 2010;116: Abstract 2812.12. Younes A, Bartlett NL, Leonard JP, et al. Brentuximab vedotin (SGN-35) forrelapsed CD30-positive lymphomas. N Engl J Med. 2010;363:1812-1821.13. Younes A, Gopal AK, Smith SE, et al. Results of a pivotal phase II study ofbrentuximab vedotin for patients with relapsed or refractory Hodgkin’s lymphoma.J Clin Oncol. 2012;30:2183-2189.14. ClinicalTrials.gov. A study of brentuximab vedotin in relapsed or refractoryCD30-positive non-Hodgkin lymphoma. http://www.clinicaltrials.gov/ct2/show/ NCT01421667. Identifier: NCT01421667.15. Jacobsen ED, Advani RH, Oki Y, et al. A phase 2 study of brentuximab vedotin in patients with relapsed or refractory CD30-positive non-Hodgkin lymphomas: interim results. Blood (ASH Annual Meeting Abstracts). 2012;120: Abstract 2746.
منابع مشابه
A Chinese patient with relapsed and refractory Hodgkin lymphoma treated with brentuximab vedotin
At present, approximately 20% of Hodgkin lymphomas (HL) are relapsed and refractory, and therapeutic methods including chemotherapy, radiotherapy, and even stem cell transplantation are unsatisfactory. Brentuximab vedotin, composed of CD30 antibody and a chemotherapeutic agent, is a new targeted drug that eradicates tumor cells by binding to the CD30 antigen on their surface. In clinical trials...
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The CD30-targeting Ab-drug conjugate brentuximab vedotin (SGN-35) was recently approved for the treatment of relapsed Hodgkin lymphoma and anaplastic large-cell lymphoma by the Food and Drug Administration. In the present study, we report the experience of the German Hodgkin Study Group with brentuximab vedotin as single agent in 45 patients with refractory or relapsed CD30(+) Hodgkin lymphoma ...
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INTRODUCTION Brentuximab vedotin (SGN-35), an anti-cluster of differentiation (CD)-30 antibody conjugated to the anti-tubulin agent monomethyl auristatin E, has demonstrated promising efficacy and tolerability in relapsed and heavily treated Hodgkin lymphoma (HL). In this study, we report the Asian experience with brentuximab vedotin in patients with relapsed or refractory CD30-positive (CD30+)...
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Brentuximab vedotin was reported to be effective and safe against refractory/relapsed Hodgkin lymphoma in cohorts of between 12 to 102 patients. Herein we report our retrospective analysis of the French experience with brentuximab vedotin used alone to treat 240 refractory/relapsed Hodgkin lymphoma patients enrolled in a named patient program between 2011 and 2013. All patients had histological...
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Brentuximab vedotin (BV) is an antibody-drug conjugate that targets CD30-positive malignancies via an anti-CD30 monoclonal antibody linked to monomethyl auristatin E, a microtubule-disrupting agent, by a protease-cleavable linker. BV has received accelerated approval from the US Food and Drug Administration for the treatment of classical Hodgkin lymphoma that has relapsed either after autologou...
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ورودعنوان ژورنال:
- Clinical advances in hematology & oncology : H&O
دوره 11 6 شماره
صفحات -
تاریخ انتشار 2013