Complete response to brentuximab vedotin in a transplant-naïve patient with relapsed CD30-positive nodular lymphocyte-predominant Hodgkin lymphoma.

نویسندگان

  • Ciara C O'Sullivan
  • Metin Ozdemirli
  • Michael Bazylewicz
  • Bruce D Cheson
چکیده

644.8. Schulz H, Rehwald U, Morschhauser F, et al. Rituximab in relapsed lympho-cyte-predominant Hodgkin lymphoma: long-term results of a phase 2 trial by theGerman Hodgkin Lymphoma Study Group (GHSG). Blood. 2008;111:109-111.9. Advani RH, Horning SJ, Hoppe RT, et al. Frontline therapy of nodularlymphocyte predominant Hodgkin lymphoma with rituximab: the StanfordUniversity experience. Blood (ASH Annual Meeting Abstracts). 2011;118:Abstract 2686.10. Eichenauer DA, Fuchs M, Pluetschow A, et al. Phase 2 study of ritux-imab in newly diagnosed stage IA nodular lymphocyte-predominant Hodg-kin lymphoma: a report from the German Hodgkin Study Group. Blood.2011;118:4363-4365.11. Fanale MA, Lai CM, McLaughlin P, et al. Outcomes of nodular lymphocytepredominant Hodgkin’s lymphoma (NLPHL) patients treated with R-CHOP.Blood (ASH Annual Meeting Abstracts). 2010;116: Abstract 2812.12. Younes A, Bartlett NL, Leonard JP, et al. Brentuximab vedotin (SGN-35) forrelapsed CD30-positive lymphomas. N Engl J Med. 2010;363:1812-1821.13. Younes A, Gopal AK, Smith SE, et al. Results of a pivotal phase II study ofbrentuximab vedotin for patients with relapsed or refractory Hodgkin’s lymphoma.J Clin Oncol. 2012;30:2183-2189.14. ClinicalTrials.gov. A study of brentuximab vedotin in relapsed or refractoryCD30-positive non-Hodgkin lymphoma. http://www.clinicaltrials.gov/ct2/show/ NCT01421667. Identifier: NCT01421667.15. Jacobsen ED, Advani RH, Oki Y, et al. A phase 2 study of brentuximab vedotin in patients with relapsed or refractory CD30-positive non-Hodgkin lymphomas: interim results. Blood (ASH Annual Meeting Abstracts). 2012;120: Abstract 2746.

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A Chinese patient with relapsed and refractory Hodgkin lymphoma treated with brentuximab vedotin

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INTRODUCTION Brentuximab vedotin (SGN-35), an anti-cluster of differentiation (CD)-30 antibody conjugated to the anti-tubulin agent monomethyl auristatin E, has demonstrated promising efficacy and tolerability in relapsed and heavily treated Hodgkin lymphoma (HL). In this study, we report the Asian experience with brentuximab vedotin in patients with relapsed or refractory CD30-positive (CD30+)...

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عنوان ژورنال:
  • Clinical advances in hematology & oncology : H&O

دوره 11 6  شماره 

صفحات  -

تاریخ انتشار 2013